HEREDITARY GINGIVAL FIBROMATOSIS PDF

Hereditary gingival fibromatosis (HGF), also known as idiopathic gingival hyperplasia, is a rare condition of gingival overgrowth. HGF is characterized as a . Hereditary, drug-induced, and idiopathic gingival overgrowth have been reported . Hereditary gingival fibromatosis can occur as an isolated. Mutation in SOS1, son-of-sevenless gene, is thought to be responsible for hereditary gingival fibromatosis. This report shows a case of.

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Hereditary Gingival Fibromatosis: A Review and a Report of a Rare Case

Commonly the patient will have mandiblular and maxilliary inflammation and overgrowth as opposed to the traditional pink, firm, and fleshy consistency of healthy gingiva. Regarding the higher rate of recurrence in children and teenagers compared to adults [ 18 ], we found it better to delay surgical intervention gingivectomy until commencement of the presurgical orthodontic phase and planned periodic visits to monitor eruption of remained permanent teeth.

The case presented in this paper differs from previous reports since she needed combined orthodontic and orthognathic treatment because of severe skeletal discrepancies of the jaws. A mutation in the SOS1 gene results in a single nucleotide insertion. Her family history was significant because her elder sister 15 years old also revealed the presence of gingival enlargement but, was not willing for treatment as it was not causing any aesthetic and functional compromise.

At the time they visited a general dental practitioner who suggested quadrant wise gingivectomy. The patient had no relevant medical history, although his maternal uncle had gingival enlargement. Usually the hyperplastic gingiva is pale pink to red and inflamed. The patient is planned for surgical removal of lesion by CO 2 laser quadrant gingivectomy. They grow faster and produce more collagen and fibronectin than fibroblasts from normal human gingiva NGF ,[ 22 ] partly under the autocrine control of TGF-beta reducing the proteolytic activities of HGF fibroblasts; which again favour the accumulation of extracellular matrix.

The symmetric form, which is the most common type of disorder, results in uniform enlargement of the gingiva that is firm, dense, resilient, insensitive fibrous tissue that covers the alveolar ridges and extends over the teeth resulting in extensive pseudo pockets. At that point it was suggested to the parents that the existing dysfunction should be solved surgically, with nitrous oxide sedation and local anesthesia.

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Scand J Dent Res. This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3. The patient showed muscle tension on mouth closing, lip strain and lip incompetency at rest Figures 3 and 4. Post-surgical healing was uneventful. It has characteristic smooth to pebbled surface with little tendency to bleed. She had no history of epilepsy or mental disorder.

Indexed in Web of Science. On palpation, mass was found to be firm and nontender. It usually begins at the time of eruption of permanent dentition but can develop with the eruption of primary dentition.

Source 1 Later on inthere was a case study done on a year-old male with severe gingival overgrowth, almost covering all teeth. Once it causes a premature stop codon, the chromosome loses four important proline -rich SH-3 binding domains in the carboxyl-terminal region of the SOS1 protein. WB Saunders Co; Her parents gigival not reveal any evidence of gingival overgrowth.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3. An occurrence of the disease has been found in two generations of this family and therefore, it heredittary be following autosomal dominant trait of inheritance.

Circles denote females and squares denote males; a slash through a symbol denotes a deceased individual. Author information Article notes Copyright and License information Disclaimer.

Disease definition Hereditary gingival fibromatosis HGF is a rare benign, slowly progressive, non-inflammatory fibrous hyperplasia of the maxillary and mandibular gingivae that generally occurs with the eruption of the permanent or more rarely the primary dentition or even at birth.

The material is in no way intended to replace professional medical care by gingiival qualified specialist and should not be used as a basis for diagnosis or heredittary.

Hereditary gingival fibromatosis

The mandibular teeth were not at all visible except in right and left posterior region. A Age of the patient: The surgery uncovered the eight permanent incisors, restoring the smile, appearance and function typical of an eight-year-old Fig. An unusual case report. The CV Mosby Company; The connective tissue was relatively avascular with scanty inflammatory cells infiltrate. The HGF may also result in diastemas, fibrmatosis tooth eruption, and facial disfigurement due to lip protrusion.

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Intraoral view of mandibular arch showing a gross generalized growth of gingiva completely covering the mandibular teeth extending from right mandibular tuberosity to left tuberosity region.

Additional information Further information on this disease Classification s 2 Gene s 3 Clinical signs and symptoms Publications in PubMed Other website s 0. Lateral cephalogram showing hereditwry deficiency and vertical growth pattern. In the second case, the external bevel technique allowed the gingivectomy and gingivoplasty to be performed without raising a flap, avoiding the need for suture, and was more conservative towards the developing DGJ.

Performing surgery after eruption of the permanent teeth reduces the rate of recurrence 2. Periodontal diseases in children and adolescents. HGF can occur as an isolated disease affecting only gingiva, or as part of a syndrome or chromosomal abnormality, and both autosomal dominant and recessive forms of this disorder have been described in the literature. It may occur singly or in association with other inherited syndromes. Clinically, a pink gingiva with marked stippling can be seen to cover almost all the tooth, in many cases preventing eruption.

Specialised Social Services Eurordis directory. Check this box if you wish to receive a copy of your message. Hereditary gingival fibromatosis Synonyms Autosomal dominant gingival hyperplasia Classification and external hereditar Specialty oral and maxillofacial surgery ICD – 10 K Although there was presence of pseudo pockets with concomitant material alba and scanty plaque, marginal inflammation was evident around the teeth. Depending on the extension of gingival enlargement, patients complain of functional and aesthetic problems.

The presented patient seemed to be a case fibromztosis nonsyndromic HGF which the isolated nature of the condition was further confirmed by a physician.