Caleva Process Solutions Another resourceful Powerpoint Presentation from Caleva Process Solutions. These selection. Advancements in Extrusion-Spheronization. More agile techniques are improving the development of multiparticulate drug-delivery systems. Extrusion Spheronization is one of them and utilized in formulation of beads and pellets. article discusses about the extrusion spheronization process and its.

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It is hygroscopic in nature which is associated with stability related problem during storage such as development of fishy odor and discoloration. Choline availability extruion the expression of TGFbeta1 and cytoskeletal proteins in the hippocampus of developing rat brain. Am Shperonization Clin Nutr. Where, F b and F a are weights before and after friability treatment, respectively.

Multiparticulate systems have undergone great development in the past decade fueled by the better understanding of their multiple roles as a suitable delivery system. Puranik PK, khan FM. It was hypothesized that the extent of moisture absorption is directly proportional to the amount of hygroscopic surface area on the encapsulated particles. Author information Copyright and License information Disclaimer.

Extrusion-spheronization: process variables and characterization.

Choline is a water-soluble essential nutrient and important for normal functioning of cells. Formulated pellets were evaluated for parameters such as flow property, morphological characteristics, hardness-friability index HFIdrug content, encapsulation efficiency, and in vitro drug release.

Therefore, nature of coating offered significant protection when the encapsulate choline exposed to water for 5 h. Optimized formulation was kept for 6 months stability study as per ICH guidelines, and there was no change in color, moisture content, drug content, and no fishy odor was observed. This dough then pressed through an spherohization. Differential scanning calorimetry thermogram of a plain choline bitartrate CBT and b CBT loaded with formulation excipients.

Industrially feasible modified extrusion-spheronization technique was selected for microencapsulation. Microencapsulation is a creation of a barrier around the core material to avoid chemical reaction and to reduce the reactivity of the core in relation to the outside environment.

Extrusion & Spheronization Pharmaceutical Technology

Dietary reference intakes for thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, panthotenic acid, biotin, and choline. Differential scanning calorimetry analysis Differential scanning calorimetry analysis was performed for the plain CBT and optimized pellet formulations to study the drug excipient interactions. Samples were ground into powder with mortar and pestle and measured on a low background quartz plate in an aluminum holder.


Fourier transform infrared Fourier transform infrared spectroscopy was used to assess the interaction between drug-polymer in solid state. Choline bitartrate was used as a core material and HSO as a coating agent which coat the drug. The final drying ensures the pellet hardness. The current review focuses on the process of extrusion-spheronization and the operational extruder types, screen pressure, screw speed, temperature, moisture content, spheronization load, speed and time and formulation excipients and drugs variables, which may affect the quality of the final pellets.

Each ml of 0. Differential scanning calorimetry analysis was performed for the plain CBT and optimized pellet formulations to study the drug excipient interactions. The powdered microparticles were dissolved in dichloromethane 5 ml in volumetric flask and made the volume with 0.

Moisture uptake and stability studies Moisture uptake by drug and encapsulated drug was studied using moisture balance MB 50C Citizen, India. In the pharmaceutical industry, pellets of medium particle sizes from to 2, micrometers are used for most applications.

J Adv Pharm Technol Res. National Academy Press; The process consists of five operations. Moisture uptake and stability studies Moisture uptake study was conducted to check hygroscopic nature of the prepared pellets.

Extrusion / Spheronization – Glatt Integrated Process Solutions

Formulation F5 and F10 showed improvement of compressibility and binding of pellet as compared to other batches. Similarly, at higher spheronization speed pellets get agglomerated due to melting of HSO at higher temperature. The narrow size distribution was indicated by small span value. Tween 80 was obtained from SD fine chemicals, Mumbai, India.

Jannin V, Cuppok Y. Table 1 Optimization of processing variables for extrusion-jacketed spheronization process.

Formulation optimizations The composition of the wax coating solution spheronizzation other excipients should be selected such that obtained pellets have desired physical characteristics, good encapsulation efficiency, drug content, and flow properties. Table 4 Moisture content and drug content of encapsulated CBT after subjecting to accelerated conditions.


The coated spheres may be used for encapsulation, compression, or direct packaging into sachets or pouches for dosing.

But, compressibility and binding capacity of pellets were relatively low therefore addition of the binder required to be added in formulation composition. It is well-recognized vital nutrient for fetal brain development and eztrusion function, having a permanent impact on cognition. The first flask was then rinsed with 10 ml of water and added to the second flask through powder funnel.

The radiation of the platinum plasma beam using JFC auto fine coater was targeted on aluminum stubs for its coating extrrusion make a layer of 2 nm thickness above the sample for 25 min. These prepared coated stubs were then placed in the vacuum chamber of a scanning electron microscopy SEM and adjusted to maximum magnification to obtain excellent quality scanning images.

Recent developments in microencapsulation of food ingredients. Join us for the multiparticulates webinar, where key considerations in designing multiparticulate formulations and processing will be discussed with representative case studies.

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To evaluate any changes in the physical surface, morphology of pellets like size and shape was analyzed using scanning electron microscope XL 30 Model, JEOLJapan. Our Mini-tablets are a popular finished dosage form presentation and offers the benefits of multiparticulates while using established tableting technology. The size uniformity and dispersity of the microspheres were represented by span value. Drug encapsulation efficiency The encapsulated micro particles equivalent to mg of CBT were accurately weighed and crushed.

The flask was then placed on a shaker for 5 h with moderate shaking intensity.

Microencapsulation method was adopted to resolve the stability problem and for this hydrogenated soya bean oil HSO was used as encapsulating agent.