TRALI: transfusion related acute lung injury. vegetales pueden brindar contra las enfermedades degenerativas, como cáncer y enfermedades cardiovascular, . 4 Within the critical care literature, significant blood transfusion can cause transfusion related acute lung injury (TRALI) which is similar to PGD in clinical and. Lesion pulmonar aguda producida por transfusion sciencedirect. This is the first case of transfusionrelated acute lung injury trali, associated with acute.

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A transfusionrelated acute lung injury, also known as trali, is a very rare complication related to transfusion of blood components even though, it is consider the main cause of mortality when we refer to adverse outcomes to this procedure, presenting mortality rates.

Acute respiratory distress syndrome – ERS

Hypotension can be treated with the administration of fluids or, in refractory cases, vasopressors. Supportive treatment was instituted in the intensive care unit after other diagnostic hypotheses were ruled out.

Am Rev Respir Dis, ; Blood transfusion was not necessary, and the surgery and postoperative period evolved without intercurrences. At the end of the surgery, blood for the determination of Hb and MCV was drawn, and the patient was extubated without intercurrences.

Por eso, es saludable que conozcamos y divulguemos esa enfermedad, sobre todo en nuestro medio. Auscultation revealed improvement of the breath sounds, with rare crackles in the bases. How to cite this article. However, the clinical presentation is characterized by a constellation of non-specific signs and symptoms common to several disorders, making for a difficult differential diagnosis.

Since the surgery was expected to be lengthy, significant bleeding was a possibility and the red blood cell count was in the lower normal limit, two units of packed-red blood cells were requested.

The electrocardiogram showed altered right bundle branch conduction and the chest X-ray was normal. There, treatment with mg of hydrocortisone IV every eight hours continued, along with ipratropium bromide and fenoterol. Thus, it is considered as a transitory hypoxemia because anesthesia restricts the spectrum of symptoms and since it is a self-limited process it might, depending on the severity of the case, have resolved by the end of the surgery 5.

Insuficiencia respiratoria aguda insuficiencia respiratoria. Therefore, the knowledge of this disorder and its dissemination, especially in our country, is important.

The last hypothesis was considered more likely and, therefore, mg of hydrocortisone IV was administered and the blood bank was contacted to make the proper arrangements with the donor.

Insuficiencia respiratoria pulmonar aguda y transfusion pdf. However, some cases might develop up to 48 hours after transfusion 5.


On auscultation, she had rare crackles and rales bilaterally, more prominent on the bases. A chest X-ray revealed interstitial infiltrate and diffuse and confluent alveolar opacities on the lower two thirds of the lung fields bilaterally Figure enfdrmedad.

Transfusion-related acute lung injury is the most common transfusion-related cause of morbidity and mortality in the United States and England, which has increased the interest on its precise diagnosis and research of its pathophysiology and prevention 1,2.

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To rule out cardiogenic pulmonary edema, an echocardiogram was done, which was normal as well as the ECG. Although the patient remained hemodynamically stable without any complaints it was decided to transfuse one unit of PRBCs tali she was actively bleeding through the drain and to avoid transfusion in the room. It is a relatively rare, lifethreatening clinical syndrome characterized by acute respiratory failure and noncardiogenic pulmonary edema during or following a blood transfusion.

Blood for arterial blood gases was drawn and a bed in the intensive care unit was requested ICU. She was taking clonazepam for two months and denied using any other medication, smoking, or alcohol, as well as any systemic diseases. Approximately 20 minutes after admission to the PARR, the results of her blood work revealed Hb 8 mg.

A year old female underwent mastectomy with microsurgical breast reconstruction under general anesthesia. This is a 36 years old female, ASA I, scheduled for a mastectomy with microsurgical reconstruction of the breast. Assuming a diagnosis of pulmonary edema, despite effective diuresis, normal blood pressure, and jugular veins on the posterior limits of the tralk muscle, it was decided to administer 20 mg of furosemide with the hypothesis of volume overload.

However, since reliable data on its epidemiology in Brazil are not available, the difficulty to diagnose, varied clinical presentation, and absence of specific laboratory data, case reports are important. Fluid administration presupposes the exclusion of fluid overload and cardiogenic pulmonary edema.

The chest X-ray had improved, with residual basilar opacities Figure 2. On the other hand, TRALI is common and notoriously underestimated due to the diversity of diagnostic hypotheses, justifying the dissemination of the knowledge of this disorder, especially in our country, where the anesthesiologist is involved directly in blood transfusions.


Trali, acute injury, transfusion, granulocytes, secondary sharp pulmonary wound to transfusion, transfusion, granulocitosis, platelet concentrates. On the chest X-ray, edema begins on dependent tali regions and perihilar region, similar to cardiogenic pulmonary edema 5.

Purpura trombocitopenica autoinmune caso clinico y revision. The patient showed progressive improvement and was discharged from the ICU 36 hours after her admission to the unit.

The authors report a case of TRALI in a patient who underwent a mastectomy fnfermedad microsurgical breast reconstruction. Since reliable data on its epidemiology in Brazil are not available, the difficulty to diagnose, varied clinical presentation, and absence of specific laboratory data, case reports are important. During the pre-anesthetic evaluation, done the day before, the patient stated she had undergone two breast surgeries under general anesthesia for removal of nodes without intercurrences.

Meanwhile, the patient developed coughing productive of frothy secretion approximately 90 minutes after the transfusion.

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In the present case, since the patient was awake, she developed cough and eliminated frothy material through the mouth, which indicated the diagnosis of pulmonary edema. Along with the high prevalence of HLA antigens in blood products implicated in TRALI, the high incidence of multiparous donors, sensitized during pregnancy by fetal antigens, is also associated with this disorder. The radiologic aspect progresses rapidly to a generalized form white-out affecting the entire lung.

The interstitial nature of the fluid, in contrast with the intra-alveolar fluid of cardiogenic pulmonary edema, despite the lack of scientific evidence to support this affirmation could possibly explain the paucity of auscultation 5. The surgery evolved without intercurrences, the patient remained hemodynamically stable, with effective urine output, and intraoperative losses were compensated by the administration of 2, mL of NS and mL of hetastarch.

Currently the patient is asymptomatic with normal pulmonary function. Data regarding the patient, as well as the complication resulting from the transfusion, were recently included in the data bank of a health agency.

In the case presented here, transfusion was done in the PARR with the patient awake and oriented allowing proper diagnosis despite the very early development of symptoms. Pitiriasis versicolor causas, sintomas y tratamiento.