Eurand’s Diffucaps® technology enables the development of once-daily controlled-release (CR) capsules or patient-friendly orally disintegrating tablet ( ODT). Download scientific diagram | ORBEXA ® Technology 3) DIFFUCAPS ® Technology: Diffucaps is a multiparticulate bead system comprised of multiple layers of. DIFFUCAPS ® technology 4) DIFFUTAB ® Technology: Diffutab technology enables customized release profiles and region-specific delivery. Diffutab.

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However, there are some problems that limit the further applications of the system, such as the selection of suitable excipients and the pharmacotechnical properties of etchnology products. TMDS time multiple action delivery system This system controls release rates for multiple ingredients within a single tablet in a programmed manner.

9. Pulsatile Drug Delivery System: Method and Technology Review | Insight Medical Publishing

An Approach for controlled drug delivery. Acid secretion is high in the afternoon and at night. As the pulsatile drug delivery achieve desired therapeutic effect and reducing side effect, so patient compliance can be obtained along with lowering dose frequency. The objective was to develop a once-daily controlled release system with a fast onset of action and reduced gastric irritancy. Current status of drug delivery technologies and future directions. Significant modification and designing of the conventional delivery systems in the form of pulsatile delivery systems ensures the time-controlled pulsatile release of bioactive compounds, which is prerequisite in the treatment of such disorders.

Roy P and Shahiwala A: Development of single unit floating-pulsatile site specific drug delivery system for chronotherapeutic release of aceclofenac. If our normal rhythm is disrupted we tend to become anxious e. System is composed of a drug-containing core and swells able polymeric coating of HPMC which slow the interaction with aqueous fluids4,8,9,11,13,14,15,16, Electrically erodible polymer gel for controlled release of drugs.

These devices have been developed to respond with changes in glucose concentration in the blood. Recent Pat Drug Deliv Formul. The conventional dry-coated tablet DC method requires core tablet preparation before, and therefore, the complicated procedure of the conventional DC method increases the manufacturing cost and the chance of failure, which may lead to a rise in core tablet supply. Gels of this type of polymer display low viscosity at ambient temperature, and exhibit a sharp increase in viscosity as the temperature rises.


Circadian rhythms Circadian rhythms are self-sustaining, endogenous oscillations that occur with a periodicity of about 24 Hours Figure. There are numerous advantages of technoloby pulsatile drug delivery systems.

Diffucaps® Customized Release Technology | Adare Pharmaceuticals | CPhI Online

OSDRC technology The conventional dry-coated tablet DC method requires core tablet preparation before, and therefore, the complicated procedure of the conventional DC method increases the manufacturing cost and the chance of failure, which may lead to a rise in core tablet supply. Eurand Minitabs combine the simplicity of tablet formulation with the sophistication of multiparticulate systems, suitable for high drug loading, and can be used as a sprinkle for pediatric and geriatric patients who have difficulty swallowing tablets.

Lipid technology—a promising drug delivery system for poorly water soluble drugs. Increasing the strength of the ultrasound resulted in a proportional increase in the amount of 5- fluorouracil released1, 2,3, Thermoresponsive pulsatile release Hydrogels that undergo reversible volume changes in response to changes in temperature are known as thermosensitive gels.

From the many temperature-sensitive polymers, poly N-isopropylacrylamide PINPAm is probably the most extensively used. When both these systems come in contact with aqueous medium, the coat emulsifies or erodes after the lag time. To achieve controlled release, a multilayered tablet constructed using two basic components, hydrophilic polymers, such as hydroxypropyl methycellulose HPMCand surface-controlling barriers. This technology can be used for sensitive drugs such as proteins.

Tablets with controlled-rate release of active substances. Microchips as controlled drug-delivery devices.

Under the influence of electric field, electro-responsive hydro gels generally bend, depending techonlogy the shape of the gel which lies parallel to the electrodes whereas deswelling diffuczps when the hydro gel lies perpendicular to the electrodes 1, 2,3,15 Light induces release In this system drug delivery is regulated by the interaction between light and material and can be achieved doffucaps combining a material that absorbs light at a desired wavelength and a material that uses energy from the absorbed light to regulate drug delivery.

Using this novel technology, SkyePharma has developed Lodotra TMcontaining a rheumathoid arthritis drug. The drug layer contains the poorly soluble drugs, osmotic agents and a suspending agent. Magnetically induced pulsatile release Use of an oscillating magnetic to regulate the drug delivery from a polymer matrix was one of the first methodologies investigated to develop an externally controlled drug delivery system. Diffutab technology enables customized release profiles and region-specific delivery.


Uniphyl theophylline, anhydrous tablets in a controlled-release system allow a 24 h dosing interval for patients.

Recent technologies in pulsatile drug delivery systems

The release controlling coating is a blend of water soluble and water insoluble polymers. Ritschel WA, Forusz H. A drug core granulated or layered onto a neutral surface is created, followed by the application of one or more rate-controlling, functional polymer membranes. Magnetically-responsive polymerized liposomes as potential oral delivery vehicles.

Drug release from intelligent gels responding to antibody concentration. Drug delivery was controlled by the rupture of the membrane. Drug release from intelligent gels responding to antibody concentration In the human body numerous kinds of bioactive compounds are exist.

These rhythms allow organism to anticipate and prepare for precise and regular environment changes. Although sustained and controlled drug delivery systems have acquired a lot of success and application in field of Pharmacy. A pulsatile drug release, where the drug is released rapidly after a well defined lag-time, could be advantageous for many drugs or therapies.

Time controlled or site specific single or multiple units are obtained by pulsatile drug delivery techniques. They are further classified into: Timing drug availability with therapeutic need.

Pulsatile drug delivery system. Lower dosages are expected upon dilution of the initial drug solution. Targeting a drug to a distal organ of gastrointestinal tract GITlike the colon, requires that the release is prevented in the two-third portion of the GIT.

Externally Regulated System 3. Saeger H, Virley P.

Diffucaps Customized Release Technology from Adare Pharmaceuticals

These systems are designed according to the circadian rhythm of the body and the drug is released as a pulse. Prior to coating with one or more polymers, a neutral core is coated with a drug substance to achieve a once-a difgucaps release profile. Open in a separate window.