DEVELOPMENTAL FLUORIDE NEUROTOXICITY A SYSTEMATIC REVIEW AND META-ANALYSIS PDF

Objective: We performed a systematic review and meta-analysis of published demiological studies of developmental fluo-. ride neurotoxicity. Developmental Fluoride Neurotoxicity: Choi et al. Respond . fluoride neurotoxicity: a systematic review and meta-. analysis. Environ Health. “Developmental Fluoride Neurotoxicity: A Systematic Review and Meta-Analysis” is a study published in Environmental Health.

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Although fluoride exposure showed inverse associations with test scores, the available exposure information did not allow a formal dose—response analysis. Measurement of intelligence by drawing test among the children in the endemic area of Al-F combined toxicosis.

Fluoride in Drinking Water: Using random-effects models, we estimated the standardized mean difference between exposed and reference groups across all studies.

Unless explicitly noted otherwise, all content licensed as indicated by RationalWiki: A preliminary exploration of IQ of 7—13 year old pupils in a fluorosis area with contamination from burning coal. The estimate of the between-study variation is incorporated into both the SE of the estimate of the common effect and the weight of individual studies, which was calculated as the inverse sum of the within and between study variance.

An Updated Collection from the Stata Journal. Because each of the intelligence tests used is designed to measure general intelligence, we used data from all eligible studies to estimate the possible effects of fluoride exposure on general intelligence. In other words, and yet again, this paper documents the risks of chronic fluoride toxicity, not water fluoridation.

J Occup Health Damage.

Inclusion criteria and data extraction. Use of materials published in EHP should be acknowledged for example,? Footnotes This study was supported by internal institutional funds. The results suggest that fluoride may be a developmental neurotoxicant that affects brain development at exposures much below those that can cause toxicity in adults Grandjean Average IQ of children in high-fluorosis area was lower than that in the reference area.

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Effect of high-fluoride water on intelligence in children. This research dates back to the s, but has not been widely cited at least in part because of limited access to Chinese journals. Exclude nonstandardized testsa 23 —0. However, as research on other neurotoxicants has shown, a shift to the left of IQ distributions in a population will have substantial impacts, especially among those in the high and low ranges of the IQ distribution Bellinger Effect of fluoride exposure on intelligence in children.

Developmental fluoride neurotoxicity: a systematic review and meta-analysis.

We evaluated the potential for publication bias using Begg and Egger tests and visual inspection of a Begg funnel plot Begg and Mazumdar ; Egger et al. The standardized weighted mean difference in IQ score between exposed and reference populations was —0. The effects of endemic fluoride poisoning on tluoride intellectual development of children in Baotou.

This review addressed a relevant public health issue with reasonable broad inclusion criteria. When the model was restricted to 9 studies that used the CRT-RC and included only drinking-water fluoride exposure Chen et al. The latter showed that dose-related deficits were found, but the studies were excluded because our meta-analyzis focused on studies with the meta-anlaysis and low-exposure groups only.

The random-effects SMD estimate was —0. Our literature search identified 39 studies, among which 36 Inclusion of this study in the meta-analysis resulted with a much smaller pooled random-effects SMD estimate and a much larger I 2 —0. The authors did not state how many reviewers performed the data extraction.

Developmental Fluoride Neurotoxicity: A Systematic Review and Meta-Analysis

Research on intelligence quotient of year-old children in a district with a high level of fluoride. Malik, Harvard School of Public Health, for the helpful advice on the meta-analysis methods. For concerns on copyright infringement please see: Reference lists of included articles were also searched.

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Lit Inf Prev Med. That is an say, pro-fluoridation science does not recommend massive amounts of fluoride being added to water supplies. Systematic Reviews in Health Care: Average IQ score was lower in children in the high-fluoride group than those in the devekopmental group. Environmental Health Perspectives ; Chin J Public Health.

Revised Edition in China. By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy PolicyTerms of Serviceand Dataset License. Message for DARE database users. It is projected that all rural residents will have access to safe public drinking water by World Bank High fluoride and low iodine environment and subclinical cretinism in Xinjiang.

Developmental fluoride neurotoxicity: a systematic review and meta-analysis.

The exposed groups had access to drinking water with fluoride concentrations up to A suitable search was performed which included a relevant Chinese database. OBJECTIVE We performed a systematic review and meta-analysis of published studies to investigate the effects of increased fluoride exposure and delayed neurobehavioral development.

Full text of the paper. However, dose-related differences in test scores occurred at a wide range of water-fluoride concentrations.

Developmental Fluoride Neurotoxicity: A Systematic Review and Meta-Analysis

Int J Pediatr Dent. The fixed-effects pooled SMD estimate was —0. Future research should include detailed individual-level information on prenatal exposure, neurobehavioral performance, and covariates for adjustment.

Analysis of Systdmatic levels and intelligence of children residing in high fluorosis areas.