The effect of hydro-alcoholic celery (Apium graveolens) leaf extract on cardiovascular parameters and lipid profile in animal model of hypertension induced by. Abstract: Apium graveolens (celery) is an edible and traditionally medicinal plant worldwide, among others for the treatment of hypertension. Celery (Apium graveolens L., Apiaceae) is one of the popular aromatic mean arterial blood pressure and heart rate in normotensive and hypertensive rats.

Author: Arazuru Nikozshura
Country: Barbados
Language: English (Spanish)
Genre: Life
Published (Last): 4 March 2018
Pages: 186
PDF File Size: 15.4 Mb
ePub File Size: 5.67 Mb
ISBN: 902-5-44233-368-6
Downloads: 48723
Price: Free* [*Free Regsitration Required]
Uploader: Akikree

The role of perivascular adipose tissue in vascular smooth muscle cell growth.

All extracts caused concentration-dependent relaxation in precontracted aortic rings with and without endothelium; the most active extracts were Dichloromethane and Ethyl Acetate extracts from A. Human isolated mammarian arterial rings. Salvianolic acid B possesses vasodilation potential through NO and its related signals in rabbit thoracic aortic rings. This study was carried out in order to investigate vasorelaxant effect of extracts obtained from A. Fructose, insulin resistance, and metabolic dyslipidemia.

Asian Pac J Trop Biomed. Thus, its diuretic effect could be one of the possible antihypertensive mechanisms of celery seeds. Ginsenoside potentiates NO-mediated neurogenic vasodilatation of monkey cerebral arteries. Aqueous extracts of two varieties of ginger Zingiber officinale inhibit angiotensin I-converting enzyme, iron IIand sodium nitroprusside-induced lipid peroxidation in the rat heart in vitro.

A green tea extract high in catechins reduces body fat and cardiovascular risks in humans.

Anti-hypertensive Herbs and their Mechanisms of Action: Part I

Nigella sativa and its protective role in oxidative stress and hypertension. These include andrographolide, deoxy,didehydroandrographolide and deoxyandrographolide Awang et al. In good health, the activity of pro-oxidants is balanced by anti-oxidative agents.

  DVR - 3016-3T PDF

In their study, Benavides et al. Due to this fact, patients with acute MI often have preexisting HTN that has been undetected or untreated. Also, chronic administration of extracts significantly increased the HR in the apiun groups, whereas the HR was decreased in negative control groups due to elevation of BP.

Anti-hypertensive Herbs and their Mechanisms of Action: Part I

Journal List Front Pharmacol v. Moreover, crude extracts with high content of deoxy,didehydroandrographolide induced dramatic hypotensive effects Awang et al. Hexanic extract was by far hraveolens more potent in lowering BP in comparison to other solvent extracts.

Hawthorns have been used for treatment of CVDs since the seventeenth century Asher et al. Uncoupling endothelial nitric oxide synthase is ameliorated by green tea in experimental diabetes by re-establishing tetrahydrobiopterin levels.

Drug therapy will be necessary if these interventions are not efficient in decreasing BP. In this good study, the authors performed antihypertensive activity of A. Effect of cymbopogon citratus and citral on vascular smooth muscle of the isolated thoracic rat aorta.

Antihypertensive Effect of Celery Seed on Rat Blood Pressure in Chronic Administration

Hydrogen sulfide mediates the vasoactivity of garlic. Vanadyl sulfate prevents fructose-induced hyperinsulinemia and hypertension in rats. Brachial arteries of coronary heart disease patients.

Rat aortic endothelial cells. Human umbilical vein endothelial cells.

High-fructose fed Wistar rats. In several countries, coriander also known as cilantro or dhania is not only used as a culinary ingredient Anilakumar et al. A review on therapeutic potential of Nigella sativa: Thus, the vasodilatory effect of components in celery extracts maybe involved in hypotensive and HR-elevating effects of this herb. The same authors also reported BBR’s vasorelaxant activity on KCl-induced contractions using the same models Zhang et al.


Tehran University Medical Journal

Mousa and Mousa, hypertenslon Peptides 32— Therefore, a shift in balance from NO to superoxide formation ensues; this is referred to as uncoupling of NOS Michel and Vanhoutte, These pathological events lead to an increased ratio of vessel wall thickness as compared to the dimensions of the arterial lumen Folkow, Overall, this may explain the increasing interest in panning out the beneficial health effects of various plants and herbs in different diseases including hypertension Tabassum and Ahmad, Phytomedicine 15— Published online Jan Saffron relaxes non-vascular muscles as well.

This is thought to occur through the reaction between NO and the sulfide components of garlic Ku et al. Assuming a homeostatic imbalance, the following signaling molecular entities become integral to the pathogenesis of hypertension Ong and Whitworth, ; Montezano and Touyz, Cell 5168— In a clinical trial, Oyama et al. Of relevant interest, it is important to note that herbal consumption appear to be the most common uypertension of CAM among CVD patients Yeh et al.

Aged garlic extract lowers blood pressure in patients with treated but uncontrolled hypertension: